News

Announcements

Guttman Lab Shines at Graduation Day! 

Guttman Lab Shines at Graduation Day! June 16, 2023, marked a special day for the Guttman Lab as we celebrated the graduation of Prashant Bhat (PhD ’23) and Wesley Huang (B.S. ’23). We proudly stood by their side as they embarked on new journeys.

Celebrating Prashant Bhat’s Thesis Defense and Everhart Distinguished Student Lecture!

Celebrating Prashant Bhat’s Thesis Defense and Everhart Distinguished Student Lecture! On May 3rd, Prashant Bhat successfully defended his thesis and delivered the prestigious Everhart Distinguished Student Lecture. We’re proud of his achievements and look forward to his year as a postdoctoral scholar in our lab before he heads to medical school at UCLA in July 2024.

 

Minds Matter Southern California

This March, Guttman Lab was honored to welcome 22 talented high school students participating in the Minds Matter Southern California program. Our lab members introduced the students to our scientific research and walked them through our microscopy technologies and the full lab bench experience.

Publication: Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome

Why are lncRNAs lowly expressed? How can they regulate their more abundant targets? Our latest paper “Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome” published in Nature Structural & Molecular Biology explores how these features are balanced to ensure target specificity and robust gene regulation via a spatial amplification mechanism. Read the Paper here

Guttman Lab Retreat 2021

Guttman lab celebrates a happy return to our favorite tradition, the annual lab retreat. This year’s event was held December 10-12 in the mountain town of Lake Arrowhead, California. Lab members presented their work, discussed next year’s goals and opportunities, and drew out a roadmap for another year of research. But that’s not all, we took plenty of time to relax, hike, and make s’mores in this idyllic mountain setting.

Welcome Noah Epstein!

Welcome Noah Epstein! Noah joins our lab as a graduate student and is interested in studying nuclear compartmentalization.

In The News

SPRITE: A New Technique For Mapping DNA In Our Nuclei

Researchers at the California Institute of Technology led by NYSCF – Robertson Investigator Mitchell Guttman, PhD, have developed a new tool called SPRITE to uncover how cells organize their DNA within the nucleus.

Read more at the NYSCF here

A map to the center of the cell

A map to the center of the cell

Researchers from the California Institute of Technology (CA,USA) have unraveled the mystery of how the genome is organized inside the nucleus. Read the article in BioTechniques

The Cartography of the Nucleus

Caltech researchers have shown how cells organize the seemingly immense genome in a clever manner so that they can conveniently find and access important genes. Understanding the delicate three-dimensional organization of the genome is crucial, particularly because alterations in DNA structure have been linked to certain diseases such as cancer and early aging. Mapping and pinpointing alterations in nuclear structure may help in finding solutions to these diseases.

Read more here

A translator of his own work

A translator of his own work

A translator of his own work 

Mitch Guttman fashioned himself a biologist as well as a builder of scientific tools, methods, and algorithms when he arrived at Caltech in 2013. Others, he thought, would translate his fundamental science into more effective treatments for patients. Today, he has a different perspective.

Read more in the Caltech Magazine here

Hushing the X Chromosome

Hushing the X Chromosome

Hushing the X Chromosome

Changes to the three-dimensional structure of DNA in the nucleus are required for X-chromosome silencing, also known as X inactivation. A single molecule called Xist is responsible for the DNA remodeling, and these structural changes are critical for chromosome silencing.

Read more here

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