News

Announcements

Moved to Chen

Dec 9, 2020 |

Guttman Lab has moved! We’re now making ourselves at home in the brand new Chen Neuroscience Research Building, a beautiful open-space center constructed with scientific collaboration in mind. Learn more about the space

Mario in Faces of Cell

Oct 28, 2020 |

Mario Blanco is featured in Faces of Cell for his work in “SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses“. Learn more

Pew

Jun 7, 2015 |

Mitch Guttman is named a Pew-Steward Scholar for cancer research. Read more at Pew and Caltech

Sloane

Feb 7, 2015 |

Mitch Guttman is named a Alfred P. Sloan fellow in computational and evolutionary molecular biology. Read more.

In The News

SPRITE: A New Technique For Mapping DNA In Our Nuclei

Jun 15, 2018

Researchers at the California Institute of Technology led by NYSCF – Robertson Investigator Mitchell Guttman, PhD, have developed a new tool called SPRITE to uncover how cells organize their DNA within the nucleus.

Read more at the NYSCF here

A map to the center of the cell

A map to the center of the cell

Jun 14, 2018

Researchers from the California Institute of Technology (CA,USA) have unraveled the mystery of how the genome is organized inside the nucleus. Read the article in BioTechniques

The Cartography of the Nucleus

Jun 7, 2018

Caltech researchers have shown how cells organize the seemingly immense genome in a clever manner so that they can conveniently find and access important genes. Understanding the delicate three-dimensional organization of the genome is crucial, particularly because alterations in DNA structure have been linked to certain diseases such as cancer and early aging. Mapping and pinpointing alterations in nuclear structure may help in finding solutions to these diseases.

Read more here

A translator of his own work

A translator of his own work

Apr 7, 2018

A translator of his own work 

Mitch Guttman fashioned himself a biologist as well as a builder of scientific tools, methods, and algorithms when he arrived at Caltech in 2013. Others, he thought, would translate his fundamental science into more effective treatments for patients. Today, he has a different perspective.

Read more in the Caltech Magazine here

Hushing the X Chromosome

Hushing the X Chromosome

Aug 5, 2016

Hushing the X Chromosome

Changes to the three-dimensional structure of DNA in the nucleus are required for X-chromosome silencing, also known as X inactivation. A single molecule called Xist is responsible for the DNA remodeling, and these structural changes are critical for chromosome silencing.

Read more here

Silencing the X Chromosome

Silencing the X Chromosome

Apr 27, 2015

Silencing the X chromosome

Scientists at Caltech developed a new approach allowing them to look at lncRNA complexes in cells and were able to identify the proteins that directly interact with the Xist RNA and, ultimately, are necessary to silence transcription of the X-chromosome. These results provide the first detailed view of how a lncRNA controls gene regulation.

Read the NIH Director’s blog here

How an RNA gene silences a whole chromosome

How an RNA gene silences a whole chromosome

Apr 27, 2015

How an RNA Gene Silences a Whole Chromosome

By studying an important lncRNA, called Xist, researchers at Caltech have discovered how an abundant class of RNA genes, called long non-coding RNAs (lncRNAs, pronounced link RNAs) can regulate key genes. The scientists identified how this RNA gathers a group of proteins and ultimately prevents women from having an extra functional X-chromosome.

Read more here

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