News
Announcements
Publication: SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking
Our latest work “SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses” is published with Cell. Read the full text at Cell.com
Welcome to Jimmy Guo!
Welcome to Jimmy Guo! Jimmy is joining us as an MD/PhD graduate student.
Welcome to Jamie Wangen!
Welcome to Jamie Wangen! The latest post-doc to join Guttman Lab.
Cell Scientist
Mitch Guttman is on 2016 “Cell Scientists to Watch”. Read the full interview
Pew
Sloane
Mitch Guttman is named a Alfred P. Sloan fellow in computational and evolutionary molecular biology. Read more.
Sontag
Guttman receives a Distinguished Scientist Award from the Sontag Foundation. Read more.
CSQ
CSQ magazine names Guttman among 10 young innovators in greater Los Angeles. Read more in CSQ
Searle
Mitch Guttman is named a 2014 Searle Scholar. Read more.
Kimmel
Mitch Guttman is named a 2014 Sidney Kimmel Scholar in cancer research. Read more.
In The News
Minding the Gaps in the Genome: An Interview with Mitch Guttman
Minding the Gaps in the Genome: An Interview with Mitch Guttman
Guttman’s lab at Caltech will continue to study lncRNAs—how they work, why they are needed, and what makes them special. Guttman recently took a break from setting up his lab to answer a few questions.
Read more here
New Research Sheds Light on M.O. of Unusual RNA Molecules
The M.O. of Unusual RNA Molecules
The entire genome is coiled and folded up in any number of ways within the nucleus of each of our cells. Think, then, of the challenge that a protein or other molecule, like RNA, faces when searching through that material to locate a target gene.
Read more here
5 questions for Mitch Guttman
5 questions for Mitch Guttman
An interview with Mitch Guttman — one of the Broad Institute’s first generation of “alumni” — who as named to the Forbes “30 Under 30: Science and Healthcare” list of rising stars. This accolade comes on the heels of another prestigious honor for Guttman, who received an NIH Early Independence Award in the fall.
Read more here
Forbes
Forbes magazine names Guttman one of their 2013 and 2014 ’30 under 30′ in science
“Lots of researchers discover genes; Guttman co-discovered a new type of gene…”
Read comment from NIH Director and more at Forbes here and here
An RNA Switch for Stem Cells
An RNA Switch for Stem Cells
A new study reveals the influence of large RNA molecules in controlling stem cells.
Read more at MIT Technology Review here
The genetic sergeants that keep stem cells stemmy
The genetic sergeants that keep stem cells stemmy
Ed Yong explains how lncRNAs act to coordinate proteins and control cell identity.
Read more here
New roles emerge for non-coding RNAs in directing embryonic development
New roles emerge for non-coding RNAs in directing embryonic development
Broad scientists discovered several years ago that the human and mouse genomes encode thousands of unusual RNAs — termed large, intergenic non-coding RNAs (lincRNAs) —but their role was almost entirely unknown. By studying more than 100 lincRNAs in ES cells, the researchers now show that these RNAs help regulate development by physically interacting with proteins to coordinate gene expression and suggest that lincRNAs may play similar roles in most cells.
Read more at here
Missing links of the transcriptome
Despite the many discoveries of the genomic era, much of the human genome remains unexplored. Researchers have now discovered the identity of some of those unknown players and introduce a vast new class of genomic characters that function directly as RNA molecules.
Read more here