Decoding the roles of non-coding RNAs in shaping nuclear structure and gene expression.
At Guttman Lab, we aim to understand how noncoding RNAs shape dynamic nuclear structure to regulate gene expression. We develop cutting-edge technologies based in biochemistry, cell biology, genomics and computational biology to address these questions.
We seek to understand fundamental principles of biological regulation within the nucleus. Our team of scientists from diverse backgrounds allows us to approach these questions from a holistic perspective with an integrated strategy. We do not make a clear distinction between experimental and computational projects; our projects are goal-centered and use all tools critical for success. When necessary, we develop new tools to answer questions that were previously inaccessible and apply these tools to decipher new paradigms and improve our understanding of essential biological functions.
In The News
As a doctoral student at Guttman Lab, Sofi developed a new way to map how cells’ nuclei are organized. Read about the fellowship at HHMI
Read the article in The Scientist
Read the overview of our research at NYSCF
Welcome Isabel Goronzy! Isabel has joined Guttman Lab as a MD/PhD graduate student.
Guttman Lab has moved! We’re now making ourselves at home in the brand new Chen Neuroscience Research Building, a beautiful open-space center constructed with scientific collaboration in mind. Learn more about the space
Mario Blanco is featured in Faces of Cell for his work in “SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses“. Learn more
Our latest work “SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses” is published with Cell. Read the full text at Cell.com
Welcome to Jimmy Guo! Jimmy is joining us as an MD/PhD graduate student.
Welcome to Jamie Wangen! The latest post-doc to join Guttman Lab.