Decoding the roles of non-coding RNAs in shaping nuclear structure and gene expression.
At Guttman Lab, we aim to understand how noncoding RNAs shape dynamic nuclear structure to regulate gene expression. We develop cutting-edge technologies based in biochemistry, cell biology, genomics and computational biology to address these questions.
We seek to understand fundamental principles of biological regulation within the nucleus. Our team of scientists from diverse backgrounds allows us to approach these questions from a holistic perspective with an integrated strategy. We do not make a clear distinction between experimental and computational projects; our projects are goal-centered and use all tools critical for success. When necessary, we develop new tools to answer questions that were previously inaccessible and apply these tools to decipher new paradigms and improve our understanding of essential biological functions.
In The News
Caltech Professor Discovers Long Intergenic Non-coding RNA to Treat Incurable Neurodevelopmental Disorder
In an in-depth Q&A session, Professor Guttman explains the important connection between long intergenic non-coding RNAs, or lincRNAs, and X chromosome inactivation. Read the full featuered interview at TouchPoints Magazine
As a doctoral student at Guttman Lab, Sofi developed a new way to map how cells’ nuclei are organized. Read about the fellowship at HHMI
Read the article in The Scientist
Welcome Noah Epstein! Noah joins our lab as a graduate student and is interested in studying nuclear compartmentalization.
Welcome Olivia Ettlin! We’re thrilled to have Olivia join us as Guttman Lab’s newest Technician-Assistant.
Congratulations to our newest graduate Abhik Banerjee! We will miss you and we look forward to seeing what exciting things await you!
Welcome Isabel Goronzy! Isabel has joined Guttman Lab as a MD/PhD graduate student.
Guttman Lab has moved! We’re now making ourselves at home in the brand new Chen Neuroscience Research Building, a beautiful open-space center constructed with scientific collaboration in mind. Learn more about the space
Mario Blanco is featured in Faces of Cell for his work in “SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses“. Learn more