Guttman Lab
Decoding the roles of non-coding RNAs in shaping nuclear structure and gene expression.
We are an integrated team of experimental and computational biologists who work together to understand how nuclear compartments control gene expression programs and cell state decisions. We believe that the strength of our science arises from the diversity of our ideas and experiences. We are committed to fostering an inclusive and diverse laboratory culture and as such welcome students, postdocs, and visiting scholars from all backgrounds to join our group.
Our Lab
We seek to understand fundamental principles of biological regulation within the nucleus. Our team of scientists from diverse backgrounds allows us to approach these questions from a holistic perspective with an integrated strategy. We do not make a clear distinction between experimental and computational projects; our projects are goal-centered and use all tools critical for success. When necessary, we develop new tools to answer questions that were previously inaccessible and apply these tools to decipher new paradigms and improve our understanding of essential biological functions.
In The News
New Insights into How SARS-CoV-2 Shuts Off the ‘Alarm System’ in Human Cells
Read the overview of our research at NYSCF
How SARS-CoV-2 Disables the Human Cellular Alarm System
Read this discussion about our paper at Caltech News
Guttman lab receives 2020 NIH Director’s Transformative Research Award
Established in 2009, this award “promotes cross-cutting, interdisciplinary approaches and is open to individuals and teams of investigators who propose research that could potentially create or challenge existing paradigms.” Read more
Announcements
Publication: SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking
Guttman lab’s Nature Reviews article discussing the role of nuclear compartmentalization is out now. Titled “Nuclear compartmentalization as a mechanism of quantitative control of gene expression”, read the full text here
Welcome Noah Epstein!
Welcome Noah Epstein! Noah joins our lab as a graduate student and is interested in studying nuclear compartmentalization.
Welcome Olivia Ettlin!
Welcome Olivia Ettlin! We’re thrilled to have Olivia join us as Guttman Lab’s newest Technician-Assistant.
Mackenzie Strehle, finalist in Caltech’s 3 Minute Thesis competition
Did you know that all calico cats are ladies? In just 3 minutes, you can learn about the X-lined biology behind this remarkable fur patterning. Congrats to graduate student Mackenzie Strehle for being a finalist in Caltech’s 3 Minute Thesis competition! Watch the video on YouTube:
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Abhik Banerjee graduates
Congratulations to our newest graduate Abhik Banerjee! We will miss you and we look forward to seeing what exciting things await you!
Welcome Isabel Goronzy!
Welcome Isabel Goronzy! Isabel has joined Guttman Lab as a MD/PhD graduate student.