B.S. Biology, Wuhan University, Wuhan, China
Ph.D. Biophysics, University of Michigan-Ann Arbor

Trained as a biophysicist, Guoming aims to bridge global gene regulation patterns discovered by genomics with local mechanistic insights provided by single-molecule case studies. His research focuses on RNA‑guided, localized mechanisms of gene control that extend beyond traditional TF–DNA interactions, with lncRNA Xist as a model system.

Google Scholar | gmgao@caltech.edu

B.Sc. Peking University, China
Ph.D. Molecular Genetics, University of Toronto

Mingkun is interested in developing innovative methods that systematically profile RNA-protein interactions throughout the RNA lifecycle and within subcellular compartments, providing critical spatial and temporal resolution of RNA-protein interactions.

Google Scholar | mingkun.wu@caltech.edu

B.S. University of California, Berkeley

Allen is studying how RNA compartmentalization and genome organization evolve over time in the nucleus. By mapping RNA and DNA in both space and time, he aims to better understand the function of lncRNAs in mammalian gene regulation.

Orcid | awchen2@lncrna.caltech.edu

B.A. Wellesley College

Linlin is working to make protein targeting more accessible by developing a pipeline for discovery and screening of new affinity reagents in a rapid, inexpensive manner. This will allow us to better target and understand protein complexes and interactions.

Google Scholar | lchen3@lncrna.caltech.edu

B.S. University of California, Berkeley

Noah is investigating the regulatory function and biophysical properties of phase-separated protein compartments in cell nuclei. He is developing a method to profile nucleic acid content and stoichiometry in compartments formed by proteins of interest.

nepstein@lncrna.caltech.edu

B.S. University of the Philippines Diliman
M.S. Georg-August-Universität Göttingen

Jolo is exploring the intricate mechanisms by which RNAs and their binding proteins regulate gene expression. His research not only leverages innovative tools developed in the lab but also involves building new tools to unravel the non-coding roles of mRNAs.

Google Scholar | jferrer@lncrna.caltech.edu

University of British Columbia (BS)

Ryan’s research focuses on engineering high-throughput, multiplexed technologies to systematically map molecular interactions at scale and uncover the higher-order principles that organize gene regulation and chromatin architecture.

rhong@lncrna.caltech.edu

The University of Tokyo (BS)

Asuka explores screening technologies to tackle questions in genomics and chemical biology. She utilizes genome-wide CRISPRi screening to investigate X chromosome inactivation mechanisms. She also applies DNA-encoded library screening to develop heterobifunctional molecules for potential therapeutic applications.

asato@lncrna.caltech.edu

Stanford University (BS, MS)

Delaney is working to develop new high-throughput single cell transcriptomic methods that are efficient and scalable.

Google Scholar | dsullivan@lncrna.caltech.edu

Stanford University (BS, MS)

Ben is developing new single cell functional genomic assays to examine how nuclear structure, chromatin states, and transcription regulators coordinate gene expression in individual cells.

Google Scholar | btyeh@lncrna.caltech.edu

B.S. Arizona State University;
Ph.D. Yale University

Amy is investigating functional and cell biological outcomes following perturbations of RNA-protein interactions found to be important from other studies within the group. Most commonly, she uses mouse embryonic stem cells as a model system, with genomic targeting carried out by CRISPR-Cas9 strategies.

Google Scholar  |  achow@caltech.edu

B.S. Biochemstry, Florida State University;
Ph.D. Cell and Molecular Biology, University of Michigan

Mario is working to develop and implement methods that can help us understand the role of RNA-protein interactions in gene regulation.

Google Scholar  |  mblanco@lncrna.caltech.edu