B.S., M.S. Biology; M.S. Psychology, Warsaw University;
Ph.D. Molecular Biology, Strasbourg University

Joanna is studying non-coding DNA and RNAs in early mammalian development and reprogramming, specifically how they regulate 3D genome organization and gene expression. Specifically, she is studying the Xist lncRNA with the goal of dissecting molecular mechanisms controlling Xist-triggered gene silencing and working to develop single cell tools to study 3D DNA and RNA interactions in the nucleus.

jjach@caltech.edu

B.A. Biology/Chemistry, St. Olaf College;
Ph.D. Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine

Jamie is investigating the role played by RNA in coordinating nuclear compartments to regulate transcription.

jwangen@lncrna.caltech.edu

B.A. University of California, Berkeley

Prashant is studying how sites of RNA processing (e.g nucleoli, nuclear speckles, histone locus bodies, and Cajal bodies) are compartmentalized in 3D structures within the nucleus in the context of normal physiology and disease. He maps the spatial compartmentalization of active genes at nuclear speckles and investigates the resulting impact this has on the kinetic efficiency of RNA splicing.

Google Scholar | pbhat@lncrna.caltech.edu

B.S. Massachusetts Inst. of Technology (MIT)

Paulomi is investigating nuclear changes that result from RNA-mediated toxicity in amyotrphic lateral sclerosis (ALS). She is developing a scalable, high-throughput technology that allows the multiplexed detection of proteins in complex with other proteins, DNA, and RNA in the nucleus to better understand mechanics of neurodegeneration.

pbhattacharya@lncrna.caltech.edu

B.A. Wellesley College

Linlin is working to make protein targeting more accessible by developing a pipeline for discovery and screening of new affinity reagents in a rapid, inexpensive manner. This will allow us to better target and understand protein complexes and interactions.

Google Scholar | lchen3@lncrna.caltech.edu

B.S. University of California, Berkeley

Noah is investigating the regulatory function and biophysical properties of phase-separated protein compartments in cell nuclei. He is developing a method to profile nucleic acid content and stoichiometry in compartments formed by proteins of interest.

nepstein@lncrna.caltech.edu

B.S. Stanford University

Isabel is investigating compartmentalization of the nucleus and the role of nuclear organization in transcription and RNA processing. She designs computational and experimental tools to understand the functional consequences of complex, multi-way interactions of DNA, RNA and proteins within the nucleus.

igoronzy@lncrna.caltech.edu

B.A. University of California, Berkeley

Jimmy is developing high-throughput genomic tools to study direct, multi-way DNA and RNA interactions.

Google Scholar | jguo@lncrna.caltech.edu

B.S. University of Minnesota, Twin Cities

Drew is studying X-chromosome counting and choice, the process by which a female mammalian cell determines which X-chromosome remains active and which is silenced. X-chromosome counting is poorly understood and requires a complex interplay of nuclear architecture, non-coding RNAs, and regulatory proteins.

Google Scholar | dhonson@lncrna.caltech.edu

B.S. California State University, Fullerton

Andrew is developing new, high-throughput, genome wide, technologies to study RNA, DNA, and nuclear proteins simultaneously. Once established, these technologies will be used to understand how RNA and DNA work with proteins to influence nuclear structure, gene expression, and cell identity.

Orcid  |  aaperez@lncrna.caltech.edu

B.S. University of Nebraska, Lincoln

Mackenzie is investigating how the lncRNA Xist interacts with a variety of protein effector molecules to mediate X chromosome inactivation in female mammals. She uses molecular biology, cell biology, and genomics approaches to understand how these RNA-protein interactions lead to stable, chromosome-wide silencing.

Google Scholar | mstrehle@lncrna.caltech.edu

Wesley is studying the highly conserved lncRNA Malat1, which is hypothesized to play a role in regulating transcription and splicing. Dysregulation of Malat1 is associated with many cancers, though its exact molecular function is unknown. Wesley is using genomic methods to uncover the molecular mechanisms by which Malat1 functions.

whuang@lncrna.caltech.edu

B.S. Biochemstry, Florida State University;
Ph.D. Cell and Molecular Biology, University of Michigan

Mario is working to develop and implement methods that can help us understand the role of RNA-protein interactions in gene regulation.

Google Scholar  |  mblanco@lncrna.caltech.edu

B.S. Arizona State University;
Ph.D. Yale University

Amy is investigating functional and cell biological outcomes following perturbations of RNA-protein interactions found to be important from other studies within the group. Most commonly, she uses mouse embryonic stem cells as a model system, with genomic targeting carried out by CRISPR-Cas9 strategies.

Google Scholar  |  achow@caltech.edu

B.S. University of California, Santa Cruz

Zahra is focused on advancing single cell SPRITE methods that will allow us to map 3D DNA and RNA interactions within tissues.

zazhar@lncrna.caltech.edu

B.S. University of California, Los Angeles

Olivia is working with several members of the lab to support their work on RNA-protein interactions. She generates valuable data that furthers the group’s research progress.

oettlin@caltech.edu