Principal Investigator

Mitchell Guttman

Professor, Division of Biology and Biological Engineering, Caltech;
Associate Director, UCLA-Caltech Medical Scientist Training Program (MD-PhD program);
Robertson Investigator, New York Stem Cell Foundation

Mitch Guttman is a Professor of Biology in the Division of Biology and Biological Engineering at the California Institute of Technology (Caltech). He received his PhD from the Department of Biology at MIT where he worked with Eric Lander at the Broad Institute of MIT and Harvard. He established his lab as an independent Fellow at the Broad Institute of MIT and Harvard prior to joining the faculty at Caltech in June 2013. He is currently an Investigator at the Heritage Medical Research Institute and a Robertson Investigator of the New York Stem Cell Foundation. He is a recipient of numerous scientific honors and awards including the NIH Director’s Early Independence Award, Pew-Steward scholar in Cancer Research, a Searle Scholar, Ben Barres Early Career Investigator at the Chan Zuckerberg Initiative, and is the recipient of the Wilson S. Stone Memorial Award from the MD Anderson Cancer Center in recognition of his “outstanding contribution to biomedical research” and a 2020 NIH Director’s Transformative Research Award.



Prashant Bhat

MD/PhD Graduate Student, Biology

B.A. University of California, Berkeley

Prashant is studying how sites of RNA processing (e.g nucleoli, nuclear speckles, histone locus bodies, and Cajal bodies) are compartmentalized in 3D structures within the nucleus in the context of normal physiology and disease. He maps the spatial compartmentalization of active genes at nuclear speckles and investigates the resulting impact this has on the kinetic efficiency of RNA splicing.

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Graduate Students

Paulomi Bhattacharya

Graduate Student, Bioengineering

B.S. Massachusetts Inst. of Technology (MIT)

Paulomi is investigating nuclear changes that result from RNA-mediated toxicity in amyotrphic lateral sclerosis (ALS). She is developing a scalable, high-throughput technology that allows the multiplexed detection of proteins in complex with other proteins, DNA, and RNA in the nucleus to better understand mechanics of neurodegeneration.

Allen W. Chen

Graduate Student, Biochemistry & Molecular Biophysics

B.S. University of California, Berkeley

Allen is studying how RNA compartmentalization and genome organization evolve over time in the nucleus. By mapping RNA and DNA in both space and time, he aims to better understand the function of lncRNAs in mammalian gene regulation.

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Linlin Chen

Graduate Student, Bioengineering

B.A. Wellesley College

Linlin is working to make protein targeting more accessible by developing a pipeline for discovery and screening of new affinity reagents in a rapid, inexpensive manner. This will allow us to better target and understand protein complexes and interactions.

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Noah Epstein

Graduate Student, Biochemistry and Molecular Biophysics

B.S. University of California, Berkeley

Noah is investigating the regulatory function and biophysical properties of phase-separated protein compartments in cell nuclei. He is developing a method to profile nucleic acid content and stoichiometry in compartments formed by proteins of interest.

Jimmy K. Guo

MD/PhD Graduate Student, Biology

B.A. University of California, Berkeley

Jimmy is studying the roles of non-coding RNAs and RNA-binding proteins (RBPs) in regulating transcription and chromatin organization. He is developing high-throughout, scalable methods to study RNA-protein interactions genome-wide.

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Drew Honson

Graduate Student, Biology

B.S. University of Minnesota, Twin Cities

Drew is studying X-chromosome counting and choice, the process by which a female mammalian cell determines which X-chromosome remains active and which is silenced. X-chromosome counting is poorly understood and requires a complex interplay of nuclear architecture, non-coding RNAs, and regulatory proteins.

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Andrew Perez

Graduate Student, Biology

B.S. California State University, Fullerton

Andrew is developing new, high-throughput, genome wide, technologies to study RNA, DNA, and nuclear proteins simultaneously. Once established, these technologies will be used to understand how RNA and DNA work with proteins to influence nuclear structure, gene expression, and cell identity.

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Mackenzie Strehle

Graduate Student, Biology

B.S. University of Nebraska, Lincoln

Mackenzie is investigating how the lncRNA Xist interacts with a variety of protein effector molecules to mediate X chromosome inactivation in female mammals. She uses molecular biology, cell biology, and genomics approaches to understand how these RNA-protein interactions lead to stable, chromosome-wide silencing.

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Benjamin Yeh

MD/PhD Graduate student (Biology)

Stanford University (BS, MS)

Ben is developing new single cell functional genomic assays to examine how nuclear structure, chromatin states, and transcription regulators coordinate gene expression in individual cells.

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Undergrad Students

Alex Burr

Undergraduate Student


Mario R. Blanco

Senior Research Scientist

B.S. Biochemstry, Florida State University;
Ph.D. Cell and Molecular Biology, University of Michigan

Mario is working to develop and implement methods that can help us understand the role of RNA-protein interactions in gene regulation.

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Amy Chow

Senior Research Scientist

B.S. Arizona State University;
Ph.D. Yale University

Amy is investigating functional and cell biological outcomes following perturbations of RNA-protein interactions found to be important from other studies within the group. Most commonly, she uses mouse embryonic stem cells as a model system, with genomic targeting carried out by CRISPR-Cas9 strategies.

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Olivia Ettlin

Lab Technician-Assistant

B.S. University of California, Los Angeles

Olivia is working with several members of the lab to support their work on RNA-protein interactions. She generates valuable data that furthers the group’s research progress.

Our Team

We are an integrated team of experimental and computational biologists who work together to understand how lncRNAs control gene expression programs and cell state decisions.

We believe that the strength of our science arises from the diversity of our ideas and experiences. We welcome students, postdocs, and visiting scholars from all backgrounds to join our group.


Join Us!


Post Docs

Jamie Wangen

Joanna Jachowicz
Group Leader, IMBA Vienna

Peter Chovanec
Postdoctoral Scholar, UCLA

Noah Ollikainen
Senior Computational Scientist, National Institutes of Health

Tony Szempruch
Senior Scientist, Cell Biology, Pfizer

Vlad Grishkevich
Senior Scientist, Celsius Therapeutics

Colleen McHugh
Assistant Professor, University of California, San Diego (Department of Biochemistry)

Graduate Students

Isabel Goronz
MD/PhD Student, UCLA

Abhik Banerjee
Child Neurology Resident, Children’s Hospital of LA

Sofia Quinodoz
HHMI Hanna Gray Fellow, Princeton University (Brangwynne lab)

Chun-Kan Chen
Assistant Professor, Washington University School of Medicine in St. Louis

Jesse Engreitz
Assistant Professor, Stanford University (Department of Genetics)

Research Staff

Zahra Azhar
PhD Student, UCLA

Erik Aznauryan
Technology Development Fellow, Wyss Institute

Dev Majumdar
Assitant Professor, M.D. College of Medicine at The University of Vermont

Ward Walkup
Senior Research Scientist, Casma Therapeutics

Charlotte Lai
Aurora Electrolysis

Ali Palla
PhD Student UCSF

Chris Chen
Harvard School of Dental Medicine

Sam Kim
MD/PhD student, Stanford School of Medicine

Vickie Trinh
PhD Student, Johns Hopkins University

Pamela Russell
Principal Bioinformatics Engineer, Fulcrum Genomics

Patrick McDonel
Director, Applied Biology Team Lead, Dyno Therapeutics

Elizabeth Soehalim
Research Assistant UCLA

Elizabeth Detmar
Clinical Laboratory Scientist, UCLA

Grant Bonesteele
Genetics Counselor, Baylor College of Medicine

Parham Peyda
MD/PhD Student, UCLA

Jasmine Thai
Clinical Laboratory Scientist, Arrowhead Regional Medical Center