News

Announcements

Andrew Perez defends his thesis

Andrew defends his PhD thesis, “ChIP-DIP: A multiplexed method for mapping proteins to DNA uncovers combinatorics controlling gene expression.” Congrats, Andrew!

Read our newest publication, “Genome organization around nuclear speckles drives mRNA splicing efficiency in Nature ►

Jimmy Guo defends his thesis

Jimmy defends his PhD thesis, “Defining the universe of functional RNA-protein interactions” in which he describes his work on CLAP and SPIDR. He’ll be returning to USC in June to also gain his MD.

Mackenzie Strehle defends her thesis

Mackenzie defends her PhD Thesis “How the Xist lncRNA silences the X, the whole X, and nothing but the X” and starts a position at Evercore Partners in New York City!

Guttman lab hosts students to learn SPRITE

Guttman lab hosts students to learn SPRITE from friends of the lab – K.V. Prasanth’s lab at the University of Illinois –
Urbana Champaign and Jennifer Phillips-Cremmins lab at UPenn.

Farewell to Our Outstanding Summer Students! 

Farewell to Our Outstanding Summer Students! August 2023 was a bittersweet moment as we bid farewell to our talented summer students, Jessica Mann (Amgen Scholars, MIT ’24) and Tanvi Ganapathy (SURF, Caltech ’26).

Baking Up Fun at Guttman Lab’s Summer Cookie Hour Challenges!

Baking Up Fun at Guttman Lab’s Summer Cookie Hour Challenges! Every Tuesday in the Guttman lab we host our summer series of weekly cookie hour baking challenges. Our lab members come together for friendly bake-offs, treats, tea, and the crowning of the Guttman Lab Bakeoff winner. It’s a delightful way to foster team spirit and satisfy our sweet tooth!

Summer lab retreat at Descanso Gardens

Visitors to Descanso Gardens may have glimpsed biologists amidst the flowers during the Guttman Lab’s summer retreat. This serene spot provided the perfect backdrop for the lab’s shared insights, creative brainstorming, and planning for our next year of research.

In The News

Featured this week in Caltech News: Prashant Bhat’s latest work on nuclear speckles

Featured this week in Caltech News: Prashant Bhat’s latest work on nuclear speckles

Featured this week in Caltech News: New work on nuclear speckles, now published in Nature, “Genome organization around nuclear speckles drives mRNA splicing efficiency“.

Previously, we tended to think of splicing as a constant—you make a pre-mRNA; you splice it. Now we know that the physical organization of the nucleus makes a big difference in the efficiency of splicing and, by extension, other processes. – Prashant Bhat, PhD
Read the article in Caltech News ▶︎

Mitch Guttman on the Active Motif Epigenetics Podcast

Mitch Guttman on the Active Motif Epigenetics Podcast

In a recent interview on the Active Motif Epigenetics Podcast with host Dr. Stefan Dillinger, Dr. Mitch Guttman discussed exploring the long non-coding RNA Xist and its role in X chromosome inactivation, as well as his lab’s development of the SPRITE method to map multi-way contacts between DNA, RNA, and proteins to better understand 3D nuclear organization.
Listen to the interview ▶︎

Revealing chromosome contours, one dot at a time

Revealing chromosome contours, one dot at a time

Nature interviews Guttman Lab in this week’s Technology Feature discussing the latest technological advances for studying 3D genome organization. In concert with the in situ microscopy renderings created at Caltech’s Cai Lab, Guttman Lab’s SPRITE method has opened the door to discovery driven proximity interactions – even long distance interactions. Even lab mascot SHARP-y made the feature! Read the full article at Nature.com

The Vast Little Library Inside of Your Cells

The Vast Little Library Inside of Your Cells

Featured this week in Caltech News: Using the latest innovation developed at Guttman Lab, RNA-DNA SPRITE, our team discovered that non-coding RNA create “compartments” within the nucleus and shepherd key molecules to precise regions in the genome. Read this review now at Caltech News

Prashant awarded de Karman Fellowship

Prashant awarded de Karman Fellowship

Reserved for graduate students going into their final year of doctoral work, the fellowship was created to recognize and support outstanding scholastic achievement. Read about Prashant’s work and the award at Caltech News

$

Contact Us