Farewell to Our Outstanding Summer Students! August 2023 was a bittersweet moment as we bid farewell to our talented summer students, Jessica Mann (Amgen Scholars, MIT ’24) and Tanvi Ganapathy (SURF, Caltech ’26).
Baking Up Fun at Guttman Lab’s Summer Cookie Hour Challenges! Every Tuesday in the Guttman lab we host our summer series of weekly cookie hour baking challenges. Our lab members come together for friendly bake-offs, treats, tea, and the crowning of the Guttman Lab Bakeoff winner. It’s a delightful way to foster team spirit and satisfy our sweet tooth!
Celebrating Prashant Bhat’s Thesis Defense and Everhart Distinguished Student Lecture! On May 3rd, Prashant Bhat successfully defended his thesis and delivered the prestigious Everhart Distinguished Student Lecture. We’re proud of his achievements and look forward to his year as a postdoctoral scholar in our lab before he heads to medical school at UCLA in July 2024.
Publication: Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome
Why are lncRNAs lowly expressed? How can they regulate their more abundant targets? Our latest paper “Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome” published in Nature Structural & Molecular Biology explores how these features are balanced to ensure target specificity and robust gene regulation via a spatial amplification mechanism. Read the Paper here
Publication: SPRITE, a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding
Want to generate higher-order 3D maps of DNA organization? Our protocol for DNA-SPRITE, ” SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding” is now live on Nature Protocols! Read the protocol paper here
Guttman lab celebrates a happy return to our favorite tradition, the annual lab retreat. This year’s event was held December 10-12 in the mountain town of Lake Arrowhead, California. Lab members presented their work, discussed next year’s goals and opportunities, and drew out a roadmap for another year of research. But that’s not all, we took plenty of time to relax, hike, and make s’mores in this idyllic mountain setting.
In The News
Nature interviews Guttman Lab in this week’s Technology Feature discussing the latest technological advances for studying 3D genome organization. In concert with the in situ microscopy renderings created at Caltech’s Cai Lab, Guttman Lab’s SPRITE method has opened the door to discovery driven proximity interactions – even long distance interactions. Even lab mascot SHARP-y made the feature! Read the full article at Nature.com
Featured this week in Caltech News: Using the latest innovation developed at Guttman Lab, RNA-DNA SPRITE, our team discovered that non-coding RNA create “compartments” within the nucleus and shepherd key molecules to precise regions in the genome. Read this review now at Caltech News
Reserved for graduate students going into their final year of doctoral work, the fellowship was created to recognize and support outstanding scholastic achievement. Read about Prashant’s work and the award at Caltech News
Caltech Professor Discovers Long Intergenic Non-coding RNA to Treat Incurable Neurodevelopmental Disorder
In an in-depth Q&A session, Professor Guttman explains the important connection between long intergenic non-coding RNAs, or lincRNAs, and X chromosome inactivation. Read the full featuered interview at TouchPoints Magazine
As a doctoral student at Guttman Lab, Sofi developed a new way to map how cells’ nuclei are organized. Read about the fellowship at HHMI
Read the article in The Scientist
Read the overview of our research at NYSCF
Read this discussion about our paper at Caltech News
Established in 2009, this award “promotes cross-cutting, interdisciplinary approaches and is open to individuals and teams of investigators who propose research that could potentially create or challenge existing paradigms.” Read more