News
Announcements
Summer lab retreat at Descanso Gardens
Visitors to Descanso Gardens may have glimpsed biologists amidst the flowers during the Guttman Lab’s summer retreat. This serene spot provided the perfect backdrop for the lab’s shared insights, creative brainstorming, and planning for our next year of research.
Minds Matter Southern California
This March, Guttman Lab was honored to welcome 22 talented high school students participating in the Minds Matter Southern California program. Our lab members introduced the students to our scientific research and walked them through our microscopy technologies and the full lab bench experience.
Publication: Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome
Why are lncRNAs lowly expressed? How can they regulate their more abundant targets? Our latest paper “Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome” published in Nature Structural & Molecular Biology explores how these features are balanced to ensure target specificity and robust gene regulation via a spatial amplification mechanism. Read the Paper here
Publication: SPRITE, a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding
Want to generate higher-order 3D maps of DNA organization? Our protocol for DNA-SPRITE, ” SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding” is now live on Nature Protocols! Read the protocol paper here
Guttman Lab Retreat 2021
Guttman lab celebrates a happy return to our favorite tradition, the annual lab retreat. This year’s event was held December 10-12 in the mountain town of Lake Arrowhead, California. Lab members presented their work, discussed next year’s goals and opportunities, and drew out a roadmap for another year of research. But that’s not all, we took plenty of time to relax, hike, and make s’mores in this idyllic mountain setting.
Publication: RNA promotes the formation of spatial compartments in the nucleus
Artwork by Inna-Marie Strazhnik/Caltech
Publication: Single-cell measurement of higher-order 3D genome organization with scSPRITE
New paper now published to Nature Biotechnology: “Single-cell measurement of higher-order 3D genome organization with scSPRITE”. This new application of our SPRITE methods measures multi-way DNA interactions around nuclear bodies, TADs, and P-E in hundreds of mouse embryonic stem cells. Read the Paper here
Publication: SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking
Guttman lab’s Nature Reviews article discussing the role of nuclear compartmentalization is out now. Titled “Nuclear compartmentalization as a mechanism of quantitative control of gene expression”, read the full text here
Welcome Noah Epstein!
Welcome Noah Epstein! Noah joins our lab as a graduate student and is interested in studying nuclear compartmentalization.
Welcome Olivia Ettlin!
Welcome Olivia Ettlin! We’re thrilled to have Olivia join us as Guttman Lab’s newest Technician-Assistant.
In The News
Revealing chromosome contours, one dot at a time
Nature interviews Guttman Lab in this week’s Technology Feature discussing the latest technological advances for studying 3D genome organization. In concert with the in situ microscopy renderings created at Caltech’s Cai Lab, Guttman Lab’s SPRITE method has opened the door to discovery driven proximity interactions – even long distance interactions. Even lab mascot SHARP-y made the feature! Read the full article at Nature.com
The Vast Little Library Inside of Your Cells
Featured this week in Caltech News: Using the latest innovation developed at Guttman Lab, RNA-DNA SPRITE, our team discovered that non-coding RNA create “compartments” within the nucleus and shepherd key molecules to precise regions in the genome. Read this review now at Caltech News
Prashant awarded de Karman Fellowship
Reserved for graduate students going into their final year of doctoral work, the fellowship was created to recognize and support outstanding scholastic achievement. Read about Prashant’s work and the award at Caltech News
Caltech Professor Discovers Long Intergenic Non-coding RNA to Treat Incurable Neurodevelopmental Disorder
In an in-depth Q&A session, Professor Guttman explains the important connection between long intergenic non-coding RNAs, or lincRNAs, and X chromosome inactivation. Read the full featuered interview at TouchPoints Magazine
Sofi Quinodoz wins HHMI Hanna Gray Fellowship
As a doctoral student at Guttman Lab, Sofi developed a new way to map how cells’ nuclei are organized. Read about the fellowship at HHMI
SARS-CoV-2 Disables Key Components of Human Cells’ Defense System
Read the article in The Scientist
New Insights into How SARS-CoV-2 Shuts Off the ‘Alarm System’ in Human Cells
Read the overview of our research at NYSCF
How SARS-CoV-2 Disables the Human Cellular Alarm System
Read this discussion about our paper at Caltech News
Guttman lab receives 2020 NIH Director’s Transformative Research Award
Established in 2009, this award “promotes cross-cutting, interdisciplinary approaches and is open to individuals and teams of investigators who propose research that could potentially create or challenge existing paradigms.” Read more