Mar 26, 2022 | New Publication
Why are lncRNAs lowly expressed? How can they regulate their more abundant targets? Our latest paper “Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome” published in Nature Structural...
Jan 10, 2022 | New Publication
Want to generate higher-order 3D maps of DNA organization? Our protocol for DNA-SPRITE, ” SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding” is now live on Nature Protocols!...
Nov 11, 2021 | New Publication
Our latest paper out now in Cell and featured on the cover! “RNA promotes the formation of spatial compartments in the nucleus”. What drives organization of RNA, DNA, and proteins in the nucleus? Learn how non-coding RNAs play a central role through a...
Aug 23, 2021 | New Publication
New paper now published to Nature Biotechnology: “Single-cell measurement of higher-order 3D genome organization with scSPRITE”. This new application of our SPRITE methods measures multi-way DNA interactions around nuclear bodies, TADs, and P-E in hundreds...
Aug 2, 2021 | New Publication
Guttman lab’s Nature Reviews article discussing the role of nuclear compartmentalization is out now. Titled “Nuclear compartmentalization as a mechanism of quantitative control of gene expression”, read the full text here
Oct 8, 2020 | New Publication
Our latest work “SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses” is published with Cell. Read the full text at Cell.com