News
Announcements
Summer lab retreat at Descanso Gardens
Visitors to Descanso Gardens may have glimpsed biologists amidst the flowers during the Guttman Lab’s summer retreat. This serene spot provided the perfect backdrop for the lab’s shared insights, creative brainstorming, and planning for our next year of research.
Guttman Lab Shines at Graduation Day!
Guttman Lab Shines at Graduation Day! June 16, 2023, marked a special day for the Guttman Lab as we celebrated the graduation of Prashant Bhat (PhD ’23) and Wesley Huang (B.S. ’23). We proudly stood by their side as they embarked on new journeys.
Celebrating Prashant Bhat’s Thesis Defense and Everhart Distinguished Student Lecture!
Celebrating Prashant Bhat’s Thesis Defense and Everhart Distinguished Student Lecture! On May 3rd, Prashant Bhat successfully defended his thesis and delivered the prestigious Everhart Distinguished Student Lecture. We’re proud of his achievements and look forward to his year as a postdoctoral scholar in our lab before he heads to medical school at UCLA in July 2024.
Minds Matter Southern California
This March, Guttman Lab was honored to welcome 22 talented high school students participating in the Minds Matter Southern California program. Our lab members introduced the students to our scientific research and walked them through our microscopy technologies and the full lab bench experience.
Publication: Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome
Why are lncRNAs lowly expressed? How can they regulate their more abundant targets? Our latest paper “Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome” published in Nature Structural & Molecular Biology explores how these features are balanced to ensure target specificity and robust gene regulation via a spatial amplification mechanism. Read the Paper here
Publication: SPRITE, a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding
Want to generate higher-order 3D maps of DNA organization? Our protocol for DNA-SPRITE, ” SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding” is now live on Nature Protocols! Read the protocol paper here
Guttman Lab Retreat 2021
Guttman lab celebrates a happy return to our favorite tradition, the annual lab retreat. This year’s event was held December 10-12 in the mountain town of Lake Arrowhead, California. Lab members presented their work, discussed next year’s goals and opportunities, and drew out a roadmap for another year of research. But that’s not all, we took plenty of time to relax, hike, and make s’mores in this idyllic mountain setting.
Publication: RNA promotes the formation of spatial compartments in the nucleus
Artwork by Inna-Marie Strazhnik/Caltech
Publication: Single-cell measurement of higher-order 3D genome organization with scSPRITE
New paper now published to Nature Biotechnology: “Single-cell measurement of higher-order 3D genome organization with scSPRITE”. This new application of our SPRITE methods measures multi-way DNA interactions around nuclear bodies, TADs, and P-E in hundreds of mouse embryonic stem cells. Read the Paper here
Publication: SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking
Guttman lab’s Nature Reviews article discussing the role of nuclear compartmentalization is out now. Titled “Nuclear compartmentalization as a mechanism of quantitative control of gene expression”, read the full text here
In The News
New Insights into How SARS-CoV-2 Shuts Off the ‘Alarm System’ in Human Cells
Read the overview of our research at NYSCF
How SARS-CoV-2 Disables the Human Cellular Alarm System
Read this discussion about our paper at Caltech News
Guttman lab receives 2020 NIH Director’s Transformative Research Award
Established in 2009, this award “promotes cross-cutting, interdisciplinary approaches and is open to individuals and teams of investigators who propose research that could potentially create or challenge existing paradigms.” Read more
Biology Graduate Student Recognized for Outstanding Achievement
Graduate student Sofia Quinodoz has been awarded the Harold M. Weintraub Graduate Student Award by the Fred Hutchinson Cancer Research Center. The award recognizes “outstanding achievement during graduate studies in the biological sciences.” Learn more at Caltech News
Mitchell Guttman has been named a Ben Barres Early Career Investigator by the Chan-Zuckerberg Initiative (CZI).
Read more at the NYSCF here
SPRITE: A New Technique For Mapping DNA In Our Nuclei
Researchers at the California Institute of Technology led by NYSCF – Robertson Investigator Mitchell Guttman, PhD, have developed a new tool called SPRITE to uncover how cells organize their DNA within the nucleus.
Read more at the NYSCF here
A map to the center of the cell
Researchers from the California Institute of Technology (CA,USA) have unraveled the mystery of how the genome is organized inside the nucleus. Read the article in BioTechniques
The Cartography of the Nucleus
Caltech researchers have shown how cells organize the seemingly immense genome in a clever manner so that they can conveniently find and access important genes. Understanding the delicate three-dimensional organization of the genome is crucial, particularly because alterations in DNA structure have been linked to certain diseases such as cancer and early aging. Mapping and pinpointing alterations in nuclear structure may help in finding solutions to these diseases.
Read more here
A translator of his own work
A translator of his own work
Mitch Guttman fashioned himself a biologist as well as a builder of scientific tools, methods, and algorithms when he arrived at Caltech in 2013. Others, he thought, would translate his fundamental science into more effective treatments for patients. Today, he has a different perspective.
Read more in the Caltech Magazine here