Guttman Lab

Decoding the roles of non-coding RNAs in shaping nuclear structure and gene expression.

We are an integrated team of experimental and computational biologists who work together to understand how nuclear compartments control gene expression programs and cell state decisions. We believe that the strength of our science arises from the diversity of our ideas and experiences. We are committed to fostering an inclusive and diverse laboratory culture and as such welcome students, postdocs, and visiting scholars from all backgrounds to join our group.

Our Research
Our Publications

Our Lab

We seek to understand fundamental principles of biological regulation within the nucleus. Our team of scientists from diverse backgrounds allows us to approach these questions from a holistic perspective with an integrated strategy. We do not make a clear distinction between experimental and computational projects; our projects are goal-centered and use all tools critical for success. When necessary, we develop new tools to answer questions that were previously inaccessible and apply these tools to decipher new paradigms and improve our understanding of essential biological functions.

Meet our Team

In The News

SPRITE: A New Technique For Mapping DNA In Our Nuclei

Jun 15, 2018

Researchers at the California Institute of Technology led by NYSCF – Robertson Investigator Mitchell Guttman, PhD, have developed a new tool called SPRITE to uncover how cells organize their DNA within the nucleus.

Read more at the NYSCF here

Announcements

Moved to Chen

Dec 9, 2020 |

Guttman Lab has moved! We’re now making ourselves at home in the brand new Chen Neuroscience Research Building, a beautiful open-space center constructed with scientific collaboration in mind. Learn more about the space

Mario in Faces of Cell

Oct 28, 2020 |

Mario Blanco is featured in Faces of Cell for his work in “SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses“. Learn more

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