Jun 14, 2018 | In The News
Researchers from the California Institute of Technology (CA,USA) have unraveled the mystery of how the genome is organized inside the nucleus. Read the article in BioTechniques
Jun 7, 2018 | In The News
Caltech researchers have shown how cells organize the seemingly immense genome in a clever manner so that they can conveniently find and access important genes. Understanding the delicate three-dimensional organization of the genome is crucial, particularly because...
Aug 5, 2016 | In The News
Hushing the X Chromosome Changes to the three-dimensional structure of DNA in the nucleus are required for X-chromosome silencing, also known as X inactivation. A single molecule called Xist is responsible for the DNA remodeling, and these structural changes are...
Apr 27, 2015 | In The News
Silencing the X chromosome Scientists at Caltech developed a new approach allowing them to look at lncRNA complexes in cells and were able to identify the proteins that directly interact with the Xist RNA and, ultimately, are necessary to silence transcription of the...
Apr 27, 2015 | In The News
How an RNA Gene Silences a Whole Chromosome By studying an important lncRNA, called Xist, researchers at Caltech have discovered how an abundant class of RNA genes, called long non-coding RNAs (lncRNAs, pronounced link RNAs) can regulate key genes. The scientists...
Oct 7, 2013 | In The News, Mitch Guttman
Minding the Gaps in the Genome: An Interview with Mitch Guttman Guttman’s lab at Caltech will continue to study lncRNAs—how they work, why they are needed, and what makes them special. Guttman recently took a break from setting up his lab to answer a few...
